Coya Therapeutics Announces Positive Interim Results of an Investigator-Initiated Open Label Study with Low-Dose IL-2 and CTLA4-Ig Combination Treatment in Five Patients with Mild to Moderate Frontotemporal Dementia ACN Newswire

Coya Therapeutics Announces Positive Interim Results of an Investigator-Initiated Open Label Study with Low-Dose IL-2 and CTLA4-Ig Combination Treatment in Five Patients with Mild to Moderate Frontotemporal Dementia

- Results from the first patient cohort (N=5) of an open-label proof of concept academic study with low-dose IL-2 and CTLA4-Ig demonstrated a rapid and durable statistically significant increase in the number and suppressive function of Tregs compared to baseline values. - Clinically, patients with Frontotemporal Dementia (FTD) demonstrated minimal to no cognitive decline throughout the study period. Treatment was well tolerated, no serious adverse events were reported, and all 5 patients completed the study.Houston, TX, Apr 24, 2025 - (ACN Newswire via SeaPRwire.com) - Coya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics intended to enhance regulatory T cell (Treg) function announced positive interim results of an investigator-initiated proof of concept open-label study with low-dose IL-2 and CTLA4-Ig combination treatment in patients with Frontotemporal Dementia (FTD). The study is led by Dr. Alireza Faridar and Dr. Stanley Appel at the Houston Methodist Neurological Institute (Houston, TX) with funding from The Peggy and Gary Edwards Endowment Fund. Study patients received subcutaneously administered CTLA4-Ig, followed by a 5-day course of low-dose IL-2 every four weeks, for a total of 22 weeks of dosing and follow-up. The study aims to enroll up to 10 patients, and these interim results include data from the first 5 patients with mild to moderate FTD who have completed the full course of treatment.Dr. Arun Swaminathan, Coya’s Chief Executive Officer followed: “The results thus far are consistent with previously published encouraging data from an open-label investigator-initiated study of patients with ALS treated with low-dose IL-2/CTLA4-Ig. This interim data in FTD provides us further confidence of our approach to target and enhance Treg biology to address devastating neurodegenerative diseases including ALS and FTD”.Previous biomarker data presented by the Company demonstrated that FTD patients exhibit a compromised immunosuppressive function of regulatory T cells (Tregs), along with increased peripheral levels of inflammatory cytokines and chemokines, dysregulation of monocytes, and systemic activation of the inflammatory cascade, supporting the critical role of the immune system in the pathophysiology of FTD.One previous study showed that a cohort of 68 patients with FTD worsened by an average of 3.57 points over a 12-month period per the Clinical Dementia Rating - Frontotemporal Lobar Degeneration (CDR‐FTLD) scale (Knopman et al. Brain 2008; 131(11): 2957-2968). In addition, patients with FTD typically have shorter survival times and more rapid rates of cognitive and functional decline compared to patients with Alzheimer’s disease (Rascovsky et al. Neurology 2005; 65(3): 397-403).Dr. Fred Grossman, Coya’s Chief Medical Officer stated: “We are excited with the results observed in this initial group of patients with this proof-of-concept study. We believe that the increase in Treg numbers and suppressive function, with subsequent anti-inflammatory biological activity still to be evaluated, underscores the potential for this low-dose IL-2/CTLA4-Ig combination to be further studied as a therapy for FTD, for which there are no currently approved treatments.”Summary of Interim Study Results Overall, treatment with low-dose IL-2 and CTLA4-Ig was well tolerated. All 5 patients enrolled in the first cohort completed the study and received the investigational treatment as planned. The most common adverse events were mild injection site reactions. No serious adverse events were reported.Treg numbers and suppressive function increased after the first treatment cycle (p < 0.01 and p < 0.05, respectively, and remained at higher significant levels throughout the treatment period.Clinical functional assessments were performed in all patients at pre-specified timepoints over the course of the study using validated tools, including the Clinical Dementia Rating - Frontotemporal Lobar Degeneration (CDR‐FTLD) scale, the Montreal Cognitive Assessment (MoCA) scale, and the Progressive Aphasia Severity Scale (PASS). Results of the functional tests show that, on average, these five FTD patients treated with low-dose IL-2 and CTLA4-Ig combination exhibited minimal to no cognitive decline over the course of the study, compared to pre-treatment values.The Company intends to publish and/or present more comprehensive data in a future peer-reviewed meeting and/or publication.About Frontotemporal DementiaFrontotemporal dementia (FTD) refers to a group of neurodegenerative disorders characterized by altered behavior and language, with a progressive decline in executive function.1 FTD affects an estimated 30,000 Americans.2 FTD is categorized clinically into various subtypes; the main three include behavioral-variant frontotemporal dementia and two language variants, semantic dementia (also known as semantic variant primary progressive aphasia) and progressive non-fluent aphasia (also known as non-fluent variant primary progressive aphasia). It's a presenile dementia, meaning it can occur in younger individuals, often between the ages of 45 and 64. The average age of onset is 58, with an average survival time of 7.5 years.1,2References1. Knopman et al. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain 2008; 131(11): 2957-29682. Rascovsky et al. Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology 2005; 65(3): 397-403About Coya Therapeutics, Inc.Headquartered in Houston, TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells (“Tregs”) to target systemic inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions, including neurodegenerative, metabolic, and autoimmune diseases, and this cellular dysfunction may lead to sustained inflammation and oxidative stress resulting in lack of homeostasis of the immune system.Coya’s investigational product candidate pipeline leverages multiple therapeutic modalities aimed at restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya’s therapeutic platforms include Treg-enhancing biologics, Treg-derived exosomes, and autologous Treg cell therapy.COYA 302 is a combination treatment comprised of low-dose IL-2 and CTLA4-Ig is an investigational therapy with a dual immunomodulatory mechanism of action intended to enhance the anti-inflammatory function of Tregs and suppress the inflammation produced by activated monocytes and macrophages. Coya is developing COYA 302 for the treatment of fatal neurogenerative diseases characterized by chronic inflammation and Treg dysfunction.For more information about Coya, please visit www.coyatherapeutics.com Forward-Looking StatementsThis press release contains “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact contained in this presentation, including information concerning our current and future financial performance, business plans and objectives, current and future clinical and preclinical development activities, timing and success of our ongoing and planned clinical trials and related data, the timing of announcements, updates and results of our clinical trials and related data, our ability to obtain and maintain regulatory approval, the potential therapeutic benefits and economic value of our product candidates, competitive position, industry environment and potential market opportunities. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” and similar expressions are intended to identify forward-looking statements.Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors including, but not limited to, those related to risks associated with the success, cost and timing of our product candidate development activities and ongoing and planned clinical trials; our plans to develop and commercialize targeted therapeutics; the progress of patient enrollment and dosing in our preclinical or clinical trials; the ability of our product candidates to achieve applicable endpoints in the clinical trials; the safety profile of our product candidates; the potential for data from our clinical trials to support a marketing application, as well as the timing of these events; our ability to obtain funding for our operations; development and commercialization of our product candidates; the timing of and our ability to obtain and maintain regulatory approvals; the rate and degree of market acceptance and clinical utility of our product candidates; the size and growth potential of the markets for our product candidates, and our ability to serve those markets; our commercialization, marketing and manufacturing capabilities and strategy; future agreements with third parties in connection with the commercialization of our product candidates; our expectations regarding our ability to obtain and maintain intellectual property protection; our dependence on third party manufacturers; the success of competing therapies or products that are or may become available; our ability to attract and retain key scientific or management personnel; our ability to identify additional product candidates with significant commercial potential consistent with our commercial objectives; ; and our estimates regarding expenses, future revenue, capital requirements and needs for additional financing.We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. Moreover, we operate in a very competitive and rapidly changing environment, and new risks may emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed herein may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Although our management believes that the expectations reflected in our forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances described in the forward-looking statements will be achieved or occur. We undertake no obligation to publicly update any forward-looking statements, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.Investor Contact:David Snyder, CFOdavid@coyatherapeutics.com CORE IRBret Shapirobrets@coreir.com 561-479-8566Media ContactsFor Coya Therapeutics:Kati Waldenburgmedia@coyatherapeutics.com212-655-0924 Copyright 2025 ACN Newswire via SeaPRwire.com.
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MyJCB App Wins “iF DESIGN AWARD 2025” JCN Newswire

MyJCB App Wins “iF DESIGN AWARD 2025”

TOKYO, Apr 24, 2025 - (JCN Newswire via SeaPRwire.com) - JCB Co., Ltd., Japan's only global payment brand, is proud to announce that MyJCB App, its cardmembers-only mobile app, has won the iF DESIGN AWARD 2025 in the Communication UX category of the User Experience (UX) division. The service design and UI/UX design were developed in collaboration with FOURDIGIT Inc.The iF DESIGN AWARD 2025 recognized the app's excellence in enhancing the user experience through its form, function, and idea, leading to its victory in the Communication UX category of the User Experience (UX) division.Award page: https://ifdesign.com/en/winner-ranking/project/myjcb-app/696672Design Approach Focused on User ExperienceJCB and FOURDIGIT have been collaborating since 2021 to enhance the MyJCB App, encompassing service design, UI/UX design, and the establishment of continuous improvement processes.For the renewal project, they developed a strategy to define the app's role in the service experience, based on a detailed analysis of user behavior and challenges. The team conducted surveys of thousands of users and in-depth interviews with over 50 participants to thoroughly analyze credit card usage patterns and customer needs across various service channels, creating a comprehensive vision for the cross-channel user experience.Following the renewal, the team has continued to improve the app through store comments, user interviews, and usage data analysis, aiming to create an app that serves all customers, regardless of their financial literacy. They remain committed to delivering safer and more convenient card services while actively listening to customer feedback.For more information, please visit: https://www.4digit.com/en/projects/myjcbAbout MyJCB App"MyJCB" is a web service exclusively for JCB cardmembers that offers features, such as viewing transaction history, checking point balance and security alert notifications. Launched in 2016, the MyJCB App underwent a significant renewal in November 2023 under the concept of "card and app integration." The renewal introduced improved visibility and accessibility, along with enhanced security features that reflect JCB's core value of customer safety and security, transforming it into a more convenient and secure app.The app allows users to sort transaction details by amount or date, and includes keyword search functionality for ease of use. Security features include "Card Usage Notifications" and "Security Status Recommendations" that suggest optimal security settings for users, supporting safe card usage.The app continues to evolve with regular updates and new features to meet the diverse needs of all cardmembers, including digital concierge services for THE CLASS and Platinum cardmembers, and customizable app themes with four design options.For more information about the MyJCB App: https://www.jcb.co.jp/myjcb/app/index.htmlFor details about the Digital Concierge feature: https://www.jcb.co.jp/promotion/digital_concierge/index.htmlAbout iF DESIGN AWARDThe iF DESIGN AWARD 2025, organized by Germany-based iF International Forum Design, is one of the world's most prestigious and longest-running design awards. This year's competition received 10,651 entries from 66 countries and territories, which were evaluated by 131 design experts from 23 countries and territories based on criteria, including differentiation, form, function, idea, and sustainability. In the User Experience (UX) division, 162 entries received awards, with only five winners from Japanese companies. https://ifdesign.com/en/About the CompaniesAbout JCBJCB is a major global payment brand and a leading credit card issuer and acquirer in Japan. JCB launched its card business in Japan in 1961 and began expanding worldwide in 1981. Its acceptance network includes about 53 million merchants around the world. JCB Cards are now issued mainly in Asian countries and territories, with more than 164 million cardmembers. As part of its international growth strategy, JCB has formed alliances with hundreds of leading banks and financial institutions globally to increase its merchant coverage and cardmember base. As a comprehensive payment solution provider, JCB commits to providing responsive and high-quality service and products to all customers worldwide.For more information, please visit: www.global.jcb/en/Head Office: Aoyama Rise Square 5-1-22 Minami Aoyama, Minato-ku, TokyoEstablished: January 1961Capital: 10.6 billion yenPresident & CEO: Takayoshi FUTAEURL: https://www.global.jcb/en/About FOURDIGIT Inc.FOURDIGIT is a design and tech company that provides essential 'design' to connect digital technology and people, creating comfortable experiences for everyone involved.Drawing on our expertise cultivated in Japan, we are expanding our services to regions across Asia where the demand for digital design is growing alongside economic development. Our objective is to deliver design and technology solutions that drive business success on a global scale. Our current office locations include Japan, Thailand, Vietnam and Malaysia.Head Office: 2F/3F 8-5-32 Tanaka Koma Building, Akasaka, Minato-ku, TokyoEstablished: July 2001Capital: 45.6 million yenRepresentative Director, CEO: Ryo TAGUCHIURL: https://www.4digit.com/enMEDIA CONTACTS:JCB (Head Office in Japan)Anna TakedaCorporate CommunicationsTel: +81-3-5778-8353Email: jcb-pr@info.jcb.co.jp Copyright 2025 JCN Newswire via SeaPRwire.com.
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MHIEC Completes Renovation of Core Facilities for Arita Municipal Recycle Plaza in Saga Prefecture JCN Newswire

MHIEC Completes Renovation of Core Facilities for Arita Municipal Recycle Plaza in Saga Prefecture

Renovation of main equipment provides for long-term stable operation, with improvements in energy efficiency to reduce CO2 emissions by 4% or moreProcessed branches and grass to be used for compost, fertilizer for home gardens, and bedding for livestockTOKYO, Apr 24, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries Environmental & Chemical Engineering Co., Ltd. (MHIEC), a part of Mitsubishi Heavy Industries (MHI) Group, has completed work on a project to renovate and expand the core facilities of Arita Municipal Recycle Plaza, a waste recycling facility in Arita-cho, Saga Prefecture, based on an order from the town received in 2023. In addition to the construction of a new facility for processing pruned branches and grass trimmings, the existing recycling treatment equipment was reconditioned to extend its operational life and improve energy efficiency.Arita Municipal Recycle Plaza was designed and built by MHI, and completed in March 1999. It processes and recycles non-combustible and bulky refuse, as well as recyclable materials (cans, glass, plastic bottles). The overall processing capacity of the facility is 12 tonnes per five hours.The core facility renovation involved upgrading the main equipment of the recycling processing plant, such as conveyors, sorting equipment, and electrical instrumentation, which had become worn and degraded after more than 20 years of operation. The renovation aims for stable operation over the long term, and improvements in energy efficiency will reduce CO2 emissions by 4% or more.The newly constructed processing facility for pruned branches and grass trimmings effectively utilizes the green waste collected from around the town for compost or spreading material (sawdust for animal bedding), with a processing capacity of 1.2 tonnes per five hours. After being stored in the receiving yard, pruned branches and grass trimmings are finely processed on crushing and pulverizing lines, and will be effectively utilized by town residents as compost or fertilizer for home gardens, or by local livestock farmers in the town for animal bedding as an alternative to straw.MHIEC succeeded MHI's environmental protection business in 2008, taking over its accumulated technological development capabilities in environmental protection systems and abundant expertise in the construction, operation, and maintenance of waste management facilities both in Japan and overseas. Based on this robust track record, the company is well positioned to propose comprehensive solutions encompassing all aspects from plant construction to operation and maintenance. Going forward, the Company will continue proactively proposing solutions for extending the service life of existing waste treatment facilities, coping with global warming, and reducing maintenance, management and other lifecycle costs, to contribute to realization of a carbon neutral society.Overview of Arita Municipal Recycle PlazaTreatment Capacity 12 tonnes per five hoursNon-combustible and bulky refuse: 10 tonnes per five hoursCans and glass: 1.8 tonnes per three hoursPlastic bottles: 0.2 tonnes per two hoursTreatment Method Crushing, sorting, and compaction Overview of the Branches and Grass Processing FacilityTreatment Capacity1.2 tonnes per five hoursTreatment MethodCrushing and pulverizing About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com.
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Israel Berhenti Seketika Semasa Negara Yahudi Menghormati dan Mengingati Mangsa Holocaust Berita

Israel Berhenti Seketika Semasa Negara Yahudi Menghormati dan Mengingati Mangsa Holocaust

(SeaPRwire) - TEL AVIV – Israel terhenti seketika apabila seluruh negara berhenti beroperasi untuk memperingati 6 juta orang Yahudi yang dibunuh oleh Nazi semasa Holocaust.Upacara rasmi negara Israel, yang diadakan di bawah tema "Dari Kedalaman: Kesakitan Pembebasan dan Pertumbuhan," berlangsung pada malam Rabu, dengan bayangan masih menyelubungi negara itu akibat pembantaian 7 Oktober, perang yang berterusan terhadap Hamas, dan 59 orang, termasuk warga Amerika, yang masih ditahan oleh pengganas Palestin di Gaza.Perdana Menteri Israel Benjamin Netanyahu membuat perkaitan antara Holocaust dan ancaman semasa yang dihadapi Israel: "Lapan puluh tahun lalu, orang Yahudi tidak berdaya. Hari ini, kita tidak lagi tidak berdaya. Negara Israel kuat, IDF kuat, dan kita akan melakukan apa sahaja yang perlu untuk mengalahkan musuh kita," katanya."Tiada keputusan, tiada resolusi yang boleh menghalang kita daripada menyelesaikan perhitungan dengan orang gasar yang keji dan dahsyat ini, yang sama teruknya dengan Nazi, yang menculik, membunuh dan merogol orang yang kita sayangi," tambah Netanyahu, merujuk kepada Hamas. mengeluarkan perisytiharan untuk menandakan peristiwa yang suram itu. "Harga yang perlu dibayar oleh manusia atas kehilangan nyawa semasa Shoah tidak akan dapat difahami atau dihargai sepenuhnya. Namun, walaupun selepas Holocaust, tanah air Yahudi yang berdaulat muncul daripada abu sebagai Negara Israel moden," katanya."Malangnya, negara kita telah menyaksikan wabak antisemitisme terburuk di tanah Amerika dalam beberapa generasi. Hampir setiap hari selepas serangan maut 7 Oktober 2023 ke atas Israel, orang Yahudi Amerika diancam di jalan-jalan kita dan di dataran awam kita – peringatan bahawa masih wujud secara tragis," tambahnya.Presiden Israel Isaac Herzog berikrar semasa acara peringatan utama negara itu untuk tidak membenarkan satu lagi pembunuhan beramai-ramai dilakukan terhadap orang Yahudi."Dari gunung ingatan ini, Yad Vashem, kami mengisytiharkan: Kami tidak akan lupa, kami tidak akan memaafkan dan kami tidak akan berdiam diri. Bukan terhadap Hamas, bukan terhadap Iran, dan bukan terhadap mereka yang ingin membahayakan kami – sama ada dengan peluru berpandu, parang, atau pembohongan," katanya.Semasa acara itu, mangsa yang terselamat daripada Holocaust, Gad Fartouk, 93, menyalakan salah satu daripada enam obor peringatan, sebelum membaca doa: "Semoga semua tebusan pulang segera. Amin."Herzog pada hari Khamis melawat Poland untuk mengetuai March of the Living di bekas kem penghapusan Auschwitz-Birkenau. Tahun ini, 80 mangsa yang terselamat berumur 80 hingga 97 tahun, kebanyakannya dibebaskan dari kem kematian Nazi, disertai oleh delegasi Israel yang terdiri daripada 10 tebusan yang dibebaskan."Kami tidak akan melupakan atau memaafkan kengerian Holocaust. Namun setiap wakil yang datang ke sini dari delegasi 7 Oktober adalah kemenangan cahaya bagi orang Yahudi, dan peringatan bahawa orang Yahudi akan wujud selama-lamanya," kata , yang berarak untuk memperingati abangnya Yossi, yang mayatnya masih ditahan di Gaza."Orang Yahudi menyucikan kehidupan, bukan kematian. Kami datang ke sini dengan harapan bahawa perjanjian antara negara dan rakyatnya akan dihormati – bahawa semua tebusan akan kembali, baik yang hidup ke rumah mereka dan yang mati ke pengebumian yang sepatutnya," tambahnya.Turut serta ialah ahli keluarga mereka yang dibunuh atau masih ditawan, serta saudara-mara yang kehilangan orang tersayang semasa perang yang berlanjutan selama 18 bulan.Antara peserta lain ialah Merrill Eisenhower Atwater, cicit kepada Gen. Dwight D. Eisenhower, yang mengetuai desakan Bersekutu untuk . Perarakan tahun ini memberi penghormatan khusus kepada pasukan Bersekutu yang membebaskan kem Nazi 80 tahun lalu.Kira-kira 120,000 mangsa Holocaust yang terselamat yang berhijrah ke Israel masih hidup, menurut data rasmi, dengan kira-kira 13,000 yang lain telah meninggal dunia dalam tahun lalu. Kira-kira 2,500 mangsa yang terselamat terjejas oleh serangan Hamas pada 7 Oktober, dengan kebanyakannya telah dipindahkan ke tempat selamat dari rumah mereka.Laporan baru-baru ini bertajuk "Vanishing Witnesses: An Urgent Analysis of the Declining Population of Holocaust Survivors," meramalkan bahawa hanya separuh daripada mangsa yang terselamat ini akan hidup dalam tempoh enam tahun, dengan hanya 30%, atau kira-kira 66,250, yang tinggal pada tahun 2035. Menjelang 2040, hanya 22,080 mangsa yang terselamat akan kekal.Ditubuhkan pada tahun 1951, Yom Hashoah diperingati setiap tahun di Israel pada hari ke-27 bulan Ibrani Nissan, yang jatuh pada bulan April atau Mei, dengan upacara, program dan testimoni mangsa yang terselamat berlangsung di seluruh komuniti Yahudi di seluruh dunia.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Hezbollah yang lemah mendorong sesetengah pihak di Lubnan untuk berbicara tentang perdamaian dengan Israel sementara AS mendorong kedua-dua pihak bersama Berita

Hezbollah yang lemah mendorong sesetengah pihak di Lubnan untuk berbicara tentang perdamaian dengan Israel sementara AS mendorong kedua-dua pihak bersama

(SeaPRwire) - Sejak pemusnahan hampir keseluruhan kepimpinan pengganas Hezbollah oleh Israel, dan sokongan daripada pentadbiran Trump, yang mana utusan khasnya ke Lebanon telah menjelaskan matlamat A.S. untuk mengehadkan kuasa dan pengaruh proksi pengganas Iran itu, angin perubahan perlahan-lahan bertiup di Beirut."Terima kasih kepada Hezbollah yang dilemahkan dan dikalahkan selepas perang dengan Israel, kita akhirnya berada dalam kedudukan untuk mengadakan perbualan tentang keamanan dengan Israel," kata Rami Naim, wartawan dan penganalisis untuk Jusoor News, kepada Digital. "Dahulu, pihak perisikan menyiasat saya dan membawa saya ke penjara kerana saya berkata kita mahu keamanan dengan Israel, tetapi sekarang saya mengatakannya secara terbuka, ya, kita mahukan normalisasi, dan ya, kita mahukan keamanan dengan Israel tanpa rasa takut." Naim telah diserang secara peribadi oleh Hezbollah tahun lepas kerana pandangan terus terangnya.Pelemahan Hezbollah, proksi Iran, dan pemilihan Joseph Aoun sebagai presiden Lebanon pada Januari 2025, mewakili titik perubahan dalam trajektori politik negara itu. Selepas lebih dua tahun kebuntuan politik, pemilihan Aoun dilihat sebagai kemenangan bagi kem anti-Hezbollah, dan nampaknya telah menjadikan perubahan dalam pendapat umum mengenai keamanan dengan Israel lebih diterima.Memuji presiden A.S., Naim berkata, "Kami percaya Trump akan mengembalikan keadaan seperti sediakala dan berusaha ke arah keamanan, menyasarkan perjanjian damai utama antara Lebanon dan Israel, yang akan memerlukan peningkatan tekanan ke atas Iran."Temu bual yang dijalankan oleh Jussor, sebuah outlet media pan-Arab, telah menekankan bahawa ramai warga Lebanon kini bersedia untuk mempertimbangkan normalisasi dengan Israel. Seorang lelaki Lebanon, yang ditemu bual di hadapan kamera dengan wajahnya ditunjukkan, berkongsi harapannya: "Saya percaya suatu hari nanti akan ada normalisasi . Ia akan mengambil masa, tetapi ia akhirnya akan berlaku."Seorang lagi yang ditemu bual mengulangi sentimen yang sama: "Israel mahukan keamanan. Mereka tidak mahu peperangan. Mereka membersihkan keadaan supaya peperangan tidak berlaku, dan kami juga mahukan keamanan. Kami sudah penat."Morgan Ortagus, timbalan utusan khas A.S. untuk Keamanan Timur Tengah, telah menekankan keperluan untuk melucutkan senjata Hezbollah bagi menstabilkan Lebanon dan membuka jalan bagi keamanan di rantau ini.Dalam sebuah pada awal bulan ini, beliau menyifatkan Hezbollah sebagai "barah" dalam Lebanon yang mesti dibuang untuk negara itu mempunyai sebarang harapan untuk pulih. Beliau berkata, "Apabila anda menghidap barah, anda tidak merawat sebahagian daripada barah dalam badan anda dan membiarkan selebihnya tumbuh dan bernanah; anda membuang barah itu." Ortagus juga mengkritik Iran kerana menyemarakkan ketidakstabilan serantau dan mengheret Lebanon ke dalam konflik yang tidak diingininya. Beliau menyatakan, "Kerajaan Lebanon tidak mahu berperang dengan Israel. Pada 8 Oktober 2023, Hezbollah dan Iran memutuskan untuk terlibat dalam peperangan... orang ramai dipaksa masuk ke dalam peperangan yang tidak diingini oleh sesiapa pun.""Kami berterima kasih kepada sekutu kami Israel kerana mengalahkan Hezbollah," kata Ortagus pada sidang akhbar di pinggir bandar tenggara Beirut, Baabda, selepas pertemuan dengan Presiden Lebanon Joseph Aoun, Associated Press melaporkan.Naim berkata bahawa walaupun orang ramai mungkin bersedia untuk keamanan, adalah elit politik Lubnan yang mesti mengambil tindakan. "Kita memerlukan Amerika untuk terus memberi tekanan kepada ahli politik Lubnan yang korup, yang telah membolehkan keupayaan ketenteraannya... Ahli politik ini mesti menyokong keamanan secara terbuka. Bukan sahaja aktivis dan wartawan yang harus mengatakannya. Pembuat keputusan mesti tampil ke hadapan."Seruan Naim untuk campur tangan antarabangsa menggariskan kepentingan berterusan pengaruh A.S. dalam hala tuju politik Lubnan. "Kami telah menderita di bawah pentadbiran Biden dan Obama, serta mereka yang telah membuat kompromi dan perjanjian dengan Iran di belakang kami, tanpa menghiraukan kepentingan kami," kata Naim."Semasa penggal pertama Trump, terdapat tekanan yang ketara ke atas Iran, yang telah menimbulkan pencerobohan di rantau ini. Walau bagaimanapun, apabila Trump meninggalkan White House, Iran membina semula keupayaannya dan menjadi lebih kuat. Kini, kami mempunyai harapan yang besar untuk . Kepulangannya ke White House akan mengubah persamaan. Apa yang membuatkan kami optimis tentang Trump ialah beliau menunaikan janjinya dan menjalankan rundingan dari kedudukan yang kuat, bukan kelemahan."Walaupun terdapat sokongan yang semakin meningkat untuk keamanan dengan Israel, isu pelarian Palestin di Lubnan kekal sebagai halangan yang ketara. Seorang lelaki yang ditemu bual oleh Jussor News menegaskan, "Saya percaya seluruh rantau ini menuju ke arah keamanan. Tetapi kami mempunyai tuntutan kami – anda tidak boleh mempunyai 500,000 rakyat Palestin yang tinggal di sini, kemudian orang Israel datang membuat keamanan dan normalisasi, dan meninggalkan mereka semua di sini bersama kami."Seorang lagi wanita memberitahu Jussor: "Kami menyokong keamanan di Lubnan. Tidak mahu berperang dalam peperangan orang lain yang tidak menguntungkan Lubnan. Berkecuali, seperti yang dikatakan oleh patriark kami: cukuplah. Kita tidak sepatutnya mencari alasan atau berkata, 'Kita mahu membebaskan Palestin' sambil kita terus memusnahkan Lubnan. Rakyat Palestin memberitahu kami, 'Bertenang, kami tidak memerlukan apa-apa daripada anda.'""Rakyat Lubnan berpecah, tetapi tidak kepada dua bahagian yang sama rata," kata Naim. "Majoriti rakyat Lubnan hari ini menyokong normalisasi dan keamanan dengan Israel. Ini bukan lagi perkara yang tabu di Lubnan. Warga Lubnan boleh berkata hari ini, 'Saya menyokong keamanan dan normalisasi kerana saya telah menderita akibat peperangan yang gagal ini. Orang Israel mahukan keamanan, dan kami mahukan keamanan. Kami mahu hidup dalam keamanan. Jadi ia adalah situasi menang-menang.'"Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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India berikrar untuk memburu pengganas ‘hingga ke hujung dunia’ ketika ketegangan dengan Pakistan meningkat selepas serangan Kashmir Berita

India berikrar untuk memburu pengganas ‘hingga ke hujung dunia’ ketika ketegangan dengan Pakistan meningkat selepas serangan Kashmir

(SeaPRwire) - sedang berikrar untuk memburu pengganas "hingga ke hujung dunia" pada Khamis ketika ketegangan dengan Pakistan meningkat berikutan insiden tembakan di wilayah Kashmir, India yang menyebabkan 26 orang terkorban.Perdana Menteri Narendra Modi berkata di perhimpunan awam bahawa "India akan mengenal pasti, menjejaki dan menghukum setiap pengganas, dalang mereka dan penyokong mereka.""Kami akan mengejar mereka hingga ke hujung dunia," lapornya.Serangan pada hari Selasa merupakan serangan terburuk dalam beberapa tahun yang menyasarkan orang awam di wilayah bergolak yang telah menyaksikan pemberontakan anti-India selama lebih tiga dekad. Lelaki bersenjata melepaskan tembakan ke arah pelancong yang kebanyakannya melawat padang rumput indah yang popular, membunuh 26 orang dan mencederakan 17 orang, menurut Reuters. Kerajaan India tidak menghasilkan sebarang bukti secara terbuka yang menghubungkan serangan itu dengan negara jirannya, tetapi mengatakan ia mempunyai hubungan "rentas sempadan" dengan Pakistan. Walau bagaimanapun, Pakistan menafikan sebarang kaitan dengan serangan itu, yang didakwa oleh kumpulan militan yang menggelarkan dirinya Kashmir Resistance.Pihak berkuasa India berkata pada hari Khamis bahawa semua visa yang dikeluarkan kepada warga Pakistan akan dibatalkan berkuat kuasa Ahad, sambil menambah bahawa semua warga Pakistan yang berada di India mesti meninggalkan negara itu sebelum visa mereka tamat tempoh berdasarkan garis masa yang disemak. Negara itu juga mengumumkan langkah-langkah lain, termasuk mengurangkan jumlah kakitangan diplomatik dan menutup satu-satunya lintasan sempadan darat yang berfungsi antara kedua-dua negara. Sebagai tindak balas, Pakistan menutup ruang udaranya untuk semua syarikat penerbangan milik India atau dikendalikan oleh India dan menggantung semua perdagangan dengan India termasuk ke dan dari mana-mana negara ketiga.Jawatankuasa Keselamatan Negara Pakistan juga mengutuk "tindakan ketenteraan" India. Ia berkata bahawa walaupun Pakistan tetap komited terhadap keamanan, ia tidak akan membenarkan sesiapa pun "melanggar kedaulatannya, keselamatan, maruah dan hak yang tidak boleh dirampas."Presiden menyampaikan "simpati terdalamnya" pada hari Selasa berikutan serangan itu."Berita yang sangat membimbangkan dari Kashmir," tulis Trump di akaun TRUTH Socialnya. "Amerika Syarikat berdiri teguh bersama India menentang Keganasan. Kami berdoa untuk jiwa mereka yang terkorban, dan untuk pemulihan mereka yang cedera. Perdana Menteri Modi, dan rakyat India yang luar biasa, mendapat sokongan penuh dan simpati terdalam kami. Hati kami bersama anda semua!" Digital’s Danielle Wallace and Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Titik Panas AS-Rusia Menjelang Rancangan Putin untuk Pangkalan Tentera Laut Afrika

(SeaPRwire) - Pentadbiran Trump memberi amaran tentang "akibat serius" berhubung rancangan Rusia untuk membuka pangkalan tentera laut di Sudan yang dilanda perang. Berita mengenai pembangunan pangkalan itu telah mencetuskan amaran luar biasa daripada , Digital diberitahu.Seorang jurucakap Jabatan Negara memberitahu Digital, "Kami menggalakkan semua negara, termasuk Sudan, untuk mengelakkan sebarang transaksi dengan sektor pertahanan Rusia."Kremlin nampaknya terdesak untuk menyertai "kelab tentera laut" kuasa global Tanduk Afrika, dengan rancangannya yang diluluskan untuk pangkalan bagi kapal perang dan kapal selam berkuasa nuklear di Port Sudan. Ini tidak jauh dari pantai Lautan Hindi dari Djibouti, di mana terdapat pangkalan U.S. dan China. Dengan kerajaan Syria yang baharu berkemungkinan akan menghalau Rusia keluar dari pangkalan mereka di Tartus, Port Sudan akan menjadi satu-satunya pangkalan tentera laut asing Rusia."Moscow melihat Sudan, kerana lokasi strategiknya, sebagai tempat yang logik untuk meluaskan jejak Rusia ke Afrika, yang dilihat oleh Putin sebagai tempat utama konfrontasi geopolitik dengan Amerika Syarikat dan China," Rebekah Koffler, seorang penganalisis risikan tentera strategik, memberitahu Digital."Rusia melihat A.S. dan China sebagai musuh utama mereka, yang mana Moscow mungkin dalam jangka panjang akan mengalami konflik kinetik. Oleh itu, Putin mahu keupayaan perisikan dan ketenteraan ditempatkan berhampiran pangkalan U.S. Djibouti dan kemudahan China," katanya."Memandangkan sudah mempunyai kehadiran tentera laut di luar Tanduk Afrika," tambah Koffler, "Rusia melihat Port Sudan sebagai hab logistik untuk pemindahan senjata, penyimpanan peluru perkakasan ketenteraan, segala jenis keupayaan peperangan.""Potensi kemudahan logistik tentera laut Rusia di Sudan akan menyokong unjuran kuasa Rusia di Laut Merah dan Lautan Hindi," John Hardie, timbalan pengarah Russia Program di Foundation for Defense of Democracies (FDD), memberitahu Digital. Dia menambah bahawa "isu ini telah mendapat kepentingan yang lebih besar bagi Moscow, memandangkan ketidakpastian mengenai masa depan kemudahan logistik tentera laut Tartusnya."Pangkalan tentera laut Rusia di Lautan Hindi mempunyai implikasi ketenteraan strategik — ia adalah jarak pelayaran yang agak dekat ke Laut Merah dan Terusan Suez, titik sempit yang dilalui oleh kira-kira 12% daripada perkapalan dunia, manakala 61% daripada trafik kapal tangki minyak global juga dikatakan menggunakan terusan itu. Koffler berkata ini menimbulkan ancaman keselamatan yang ketara."Jika Rusia merasakan peningkatan yang akan berlaku terhadap Rusia, katakan di Ukraine — seperti penempatan pasukan NATO yang akan datang atau langkah ekonomi yang drastik yang direka untuk menjejaskan ekonomi Rusia — Saya tidak akan menolak kemungkinan bahawa Putin boleh membenarkan sesuatu yang mengganggu untuk mengeksploitasi titik sempit dan menjejaskan atau mengganggu perkapalan global, sebagai cara untuk menghalang tindakan Barat yang mengancam Rusia."Perjanjian yang membenarkan Moscow membina pangkalan tentera telah diberikan lampu hijau, walaupun terdapat cabaran logistik yang serius yang terlibat. "Perjanjian antara Sudan dan Rusia telah dimuktamadkan pada bulan Februari, berikutan pertemuan antara Menteri Luar Sudan Ali Yusef Sharif dan Menteri Luar Rusia Sergei Lavrov di Moscow," jelas Koffler.Oleh itu, komen-komen yang keras kepada Digital daripada Jabatan Negara bahawa "Amerika Syarikat menyedari perjanjian yang dilaporkan antara Rusia dan SAF [Angkatan Tentera Sudan] mengenai penubuhan kemudahan tentera laut Rusia di pantai Sudan. Kami menggalakkan semua negara, termasuk Sudan, untuk mengelakkan sebarang transaksi dengan sektor pertahanan Rusia, yang boleh mencetuskan akibat yang serius, berpotensi termasuk sekatan ke atas entiti atau individu yang berkaitan dengan transaksi tersebut."Bergerak maju dengan kemudahan sedemikian atau sebarang bentuk kerjasama keselamatan dengan Rusia akan terus mengasingkan Sudan, memburukkan lagi konflik semasa, dan berisiko menjejaskan lagi kestabilan serantau."Di daratan (yang sangat) kering iaitu Sudan, keadaan pada hari Isnin di sekitar bandar Al Fasher dan kem pelarian Zamzam yang besar berhampiran di wilayah Darfur adalah "mengerikan," Pembantu Setiausaha Agung PBB Tom Fletcher menyiarkan., antara SAF kerajaan dan Rapid Support Forces (RSF) pemberontak, baru sahaja melepasi ulang tahun kedua yang mengerikan. Puluhan ribu telah terbunuh, dan dianggarkan 13 juta orang telah kehilangan tempat tinggal dari rumah mereka. PBB menyifatkannya sebagai krisis kemanusiaan terburuk di dunia, dan UNICEF menggelarnya "neraka di bumi.""Tidak keterlaluan untuk menyatakan kebrutalan dan kemusnahan serangan RSF ke atas Zamzam (kem pelarian)," penyelidik Sudan Eric Reeves memberitahu Digital minggu ini. "Kem yang telah wujud sejak 2004 tidak lagi wujud, walaupun ia telah berkembang kepada lebih daripada 500,000 orang."Secara tidak menyenangkan, Reeves menambah bahawa "kematian sebenar baru sahaja bermula. Hampir seluruh penduduk Zamzam telah melarikan diri, dan ke semua arah ancaman keganasan RSF kekal. Ini mewujudkan ketidakamanan yang menghalang pekerja kemanusiaan daripada mencapai orang yang bertaburan ini. Jumlah yang sangat besar akan mati sama ada akibat keganasan RSF atau kekurangan makanan, air dan tempat tinggal."Seramai 30 lagi dilaporkan terbunuh pada hari Selasa dalam serangan RSF baharu ke atas Al Fasher. Dan baru minggu lepas, pemberontak RSF mengumumkan mereka menubuhkan kerajaan mereka sendiri. Jabatan Negara memberitahu Digital, "Amerika Syarikat sangat prihatin tentang pengisytiharan Rapid Support Forces (RSF) dan pelakon yang selaras dengan kerajaan selari di Sudan. Percubaan untuk menubuhkan kerajaan selari ini tidak membantu bagi tujuan keamanan dan keselamatan dan berisiko memecahbelahkan negara secara de facto.""Ia hanya akan terus menjejaskan kestabilan negara, mengancam integriti wilayah Sudan, dan menyebarkan ketidakstabilan yang lebih luas ke seluruh rantau. Amerika Syarikat telah menjelaskan bahawa kepentingan kami adalah dalam pemulihan keamanan dan penamatan ancaman yang ditimbulkan oleh konflik di Sudan terhadap kestabilan serantau. Jalan terbaik untuk keamanan dan kestabilan ialah penghentian permusuhan yang segera dan berkekalan supaya proses menubuhkan kerajaan awam dan membina semula negara dapat dimulakan," kata jurucakap itu.Caleb Weiss, editor Long War Journal FDD dan juga Pengurus Program Pembelotan di Bridgeway Foundation, meletakkan sebahagian daripada kesalahan kerana tidak menamatkan perang Sudan pada . Dia memberitahu Digital bahawa ia "gagal memfasilitasi sebarang rundingan/pengantaraan damai yang bermakna atau bersikap tegas terhadap penyokong luar pelbagai kumpulan untuk benar-benar membuat mereka serius dalam percubaan rundingan sebelumnya. Di sinilah pentadbiran Biden gagal."Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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5 petikan daripada Kardinal Robert Sarah, seorang tokoh kegemaran dalam kalangan konservatif untuk menggantikan Pope Francis Berita

5 petikan daripada Kardinal Robert Sarah, seorang tokoh kegemaran dalam kalangan konservatif untuk menggantikan Pope Francis

(SeaPRwire) - Kardinal Robert Sarah – yang diperjuangkan oleh konservatif sebagai mencerminkan kepausan yang berdoktrin dan berfikiran liturgi seperti Paus John Paul II dan Benedict XVI – adalah antara mereka yang dipertimbangkan untuk menggantikan Seorang kardinal Afrika dari Guinea, Sarah, 79, dilihat sebagai pembawa panji rohani dan teologi bagi penganut Katolik konservatif, memandangkan pengkritik Francis berpendapat bahawa mendiang paus itu terlalu dipengaruhi oleh sekularisme moden. Sarah sebelum ini mengetuai pejabat amal Vatican Cor Unum dan sering bertelagah dengan Francis. Perbezaan ideologi mereka menjadi lebih serius apabila Sarah dan Benedict – yang bersara sebagai pemangku paus pada tahun 2013 – bersama-sama menulis sebuah buku berjudul "From the Depths of Our Hearts: Priesthood, Celibacy and the Crisis of the Catholic Church." Buku 2020 itu menyokong "keperluan" untuk terus membujang bagi paderi Ritus Latin dan keluar ketika Francis sedang mempertimbangkan sama ada untuk membenarkan paderi yang sudah berkahwin di Amazon untuk menangani kekurangan paderi di sana. Akibatnya, Francis memecat setiausaha Benedict, Archbishop Georg Gaenswein, dari jawatan rumah tangga paus beliau, dan beberapa bulan kemudiannya, beliau mengundurkan Sarah selepas beliau mencapai umur 75 tahun. Prospek seorang paus bersara cuba mempengaruhi paus yang memerintah mewujudkan senario yang telah diberi amaran oleh peguam kanun dan ahli teologi apabila Benedict memutuskan untuk mengekalkan jubah putih kepausan dalam persaraan sebagai "pope emeritus." Skandal itu reda selepas Benedict menarik diri sebagai pengarang bersama.Sebenarnya buku Sarah pada tahun 2019 yang lebih menimbulkan kegemparan dalam kalangan penganut Kristian konservatif selepas pemergian Francis. Sarah telah menyifatkan "The Day Is Now Far Spent" sebagai buku beliau yang paling penting. Di dalamnya, kardinal itu mengecam bagaimana Eropah dan tamadun Barat telah berpaling daripada agama Kristian dan menderita akibat cabaran ideologi yang dibawa oleh migrasi besar-besaran. Sebaliknya, Francis secara terbuka dan Naib Presiden JD Vance – seorang yang baru memeluk agama Katolik – berhubung tindakan keras mereka terhadap imigresen haram. Vance, salah seorang daripada orang kenamaan terakhir yang bertemu dengan Francis pada Ahad Easter sebelum pemergiannya, telah merujuk kepada Pope John Paul II – yang ideologinya lebih serupa dengan Sarah – dalam ucapan awam baru-baru ini. Di Munich Security Conference, Vance memuji John Paul II sebagai "salah seorang juara demokrasi yang paling luar biasa" ketika menekankan . Naib presiden juga meraikan seruan John Paul II untuk evangelisasi baru di National Catholic Prayer Breakfast di Washington, D.C.Sarah bersama-sama menulis dua buku lain – "God or Nothing: A Conversation on Faith" pada tahun 2015 dan The Power of Silence: Against the Dictatorship of Noise pada tahun 2017 – kedua-duanya dengan wartawan Perancis Nicolas Diat. Berikut adalah beberapa petikan penting oleh Sarah yang diketengahkan menjelang pengebumian Francis pada akhir minggu ini. Konklav paus akan bersidang dalam beberapa minggu akan datang untuk memilih pemimpin baru Gereja Katolik. Sarah berhujah bahawa Barat telah memutuskan hubungan dengan dalam "The Day is Now Far Spent." "Barat tidak lagi tahu siapa dirinya, kerana ia tidak lagi tahu dan tidak mahu tahu siapa yang menjadikannya, siapa yang menubuhkannya, sebagaimana ia dahulu dan sebagaimana ia sekarang. Barat enggan mengakui akar Kristiannya.""Dengan kehilangan kepercayaannya, Eropah juga telah kehilangan sebab untuk wujud. Ia sedang mengalami kemerosotan yang membawa maut dan menjadi tamadun baru, yang terputus daripada akar Kristiannya."Sarah berhujah bahawa ideologi gender adalah penghinaan kepada ciptaan Tuhan dan tidak boleh mengubah secara fundamental sama ada seseorang itu lelaki atau perempuan dalam "The Day is Now Far Spent." "Ideologi gender adalah penolakan Lucifer untuk menerima sifat seksual daripada Tuhan."Dalam wawancara Mac 2019 dengan penerbitan Perancis "Valeurs Actuelles," Sarah dilaporkan mengkritik peranan Gereja Katolik dalam menyokong dasar migrasi besar-besaran di Eropah, sambil menyatakan bahaya yang disebabkan kepada pendatang itu sendiri. "Semua pendatang yang tiba di Eropah tidak berwang, tanpa kerja, tanpa maruah," Sarah "Adakah ini yang Gereja mahukan? Gereja tidak boleh bekerjasama dengan bentuk perhambaan baru ini yang telah menjadi migrasi besar-besaran."Dalam "The Power of Silence: Against the Dictatorship of Noise," Sarah berhujah bahawa gangguan moden memisahkan manusia daripada Tuhan."Gangguan adalah alat syaitan untuk memutuskan hubungan manusia dengan Tuhan."Dalam "God or Nothing: A Conversation on Faith," Sarah menegaskan bahawa kesetiaan seseorang mesti kepada Kristus – dan bukannya kepada populariti atau politik – dan berulang kali menentang relativisme moral dalam norma keluarga dan masyarakat. "Gereja bukanlah organisasi manusia. Ia tidak tertakluk kepada fesyen hari ini atau angin doktrin. Ia mesti setia kepada Kristus.""Tuhan atau tiada apa-apa: tidak ada pilihan lain. Mereka yang memilih Tuhan mempunyai segala-galanya. Mereka yang memilih tiada apa-apa akan hilang.""Jika kebenaran tidak lagi wujud, jika semuanya relatif, maka manusia menjadi hamba kepada nafsunya."Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Rusia dipersalahkan atas serangan semalaman ke atas Kyiv yang mengorbankan sekurang-kurangnya 9 orang, mencederakan berpuluh-puluh orang, termasuk kanak-kanak Berita

Rusia dipersalahkan atas serangan semalaman ke atas Kyiv yang mengorbankan sekurang-kurangnya 9 orang, mencederakan berpuluh-puluh orang, termasuk kanak-kanak

(SeaPRwire) - Pihak berkuasa mengatakan Rusia bertanggungjawab atas serangan peluru berpandu dan dron semalaman ke atas Kyiv yang membunuh sembilan orang dan mencederakan 70 yang lain, termasuk kanak-kanak.Kyiv City Military Administration berkata di saluran Telegramnya bahawa Rusia menyerang Kyiv dengan dron dan peluru berpandu balistik. Sekurang-kurangnya 45 dron dikesan, kata pihak pentadbiran, sambil menambah bahawa Ukraine's Air Force akan mengemas kini angka tersebut kemudian.Serangan itu, yang bermula sekitar pukul 1:00 pagi, mengenai sekurang-kurangnya lima kawasan kejiranan di Kyiv. Di daerah Sviatoshynkskyi, kebakaran berlaku di sebuah bangunan kediaman yang rosak dalam serangan itu. Lebih banyak kebakaran dilaporkan di daerah Shevchenkivsky dan Holosiivskyi.Sekurang-kurangnya 42 orang telah dimasukkan ke hospital, kata Ukraine's State Emergency Service. Pasukan pertama bertugas sehingga pagi, menemui mayat di bawah runtuhan.Serangan itu berlaku beberapa jam selepas rundingan damai kelihatan terhenti, dengan President Donald Trump mengecam Presiden Ukraine Volodymyr Zelenskyy, dengan mengatakan beliau melanjutkan "medan pembunuhan" dengan menolak menyerahkan Crimea kepada Rusia sebagai sebahagian daripada potensi pelan damai. Kemudian pada hari itu, Trump berkata "lebih sukar" untuk berurusan dengan Zelenskyy berbanding Rusia.Zelenskyy telah berkata beberapa kali bahawa mengiktiraf wilayah yang diduduki sebagai Rusia adalah garis merah bagi negaranya.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Badan pengawas nuklear menggesa ‘percaya tetapi sahkan’ bahawa Iran melibatkan diri dalam rundingan dengan niat baik

(SeaPRwire) - Masih banyak yang tidak diketahui mengenai kemajuan rundingan Washington, tetapi ketua badan pengawas nuklear PBB, International Atomic Energy Agency (IAEA), berkata masyarakat antarabangsa mesti "percaya tetapi sahkan" bahawa Tehran melibatkan diri dalam rundingan dengan niat baik.AS dan Iran dijadualkan mengadakan rundingan tidak langsung ketiga pada hari Sabtu, yang akan membincangkan aspek teknikal program nuklear Iran, serta rundingan politik, menurut laporan.Ketua Pengarah IAEA, Rafael Grossi telah memuji rundingan AS-Iran yang diantarai oleh Oman, tetapi berkata agensi nuklear utama itu belum lagi diminta untuk membantu dalam rundingan, walaupun beliau telah berkomunikasi dengan utusan Timur Tengah, Steve Witkoff."Saya rasa ada jangkaan umum bahawa ini berjalan lancar, dan perjanjian itu disahkan oleh IAEA," kata Grossi kepada wartawan dari Washington, D.C., pada hari Rabu. "Adalah baik Amerika Syarikat dan Iran mempunyai perbualan langsung. Sudah tentu, terdapat proses selari."Kita mesti menumpukan perhatian. Kita mesti mengelakkan Iran atau menghalang Iran daripada mendapatkan senjata. Ini adalah objektifnya."Grossi berkata bahawa dari perspektif bukan sahaja agensi nuklear utama, tetapi dari pemimpin dunia yang telah beliau berkomunikasi, terdapat "tahap jangkaan" bahawa selepas perjanjian politik dimuktamadkan antara Washington dan Tehran, IAEA yang akan menjadikan terma nuklear itu "kredibel" dan "boleh disahkan.""Mereka semua menjangkakan IAEA untuk masuk campur pada masa yang tepat," katanya. "Kami bersedia untuk menyokong, untuk menjadikan perkara ini kredibel. Dalam erti kata lain, mereka mungkin mempunyai perjanjian politik, tetapi kemudian kita perlu menjadikannya boleh disahkan." Digital memperoleh salinan ucapan Menteri Luar Iran, Abbas Araghchi — yang pergi ke China pada hari Rabu untuk dilaporkan membincangkan kemajuan dalam rundingan nuklear — yang dijadualkan untuk disampaikan di Carnegie International Nuclear Policy Conference, walaupun beliau tidak pernah menyampaikan ucapan itu disebabkan oleh permintaan perubahan format oleh Tehran yang ditolak oleh tuan rumah.Tetapi dalam ucapannya, beliau akan meletakkan Iran sebagai penyokong bukan proliferasi nuklear dan berkata kedudukan Iran telah "disalah anggap."Sejak pengunduran AS daripada Joint Comprehensive Plan of Action (JCPOA), yang Tehran telah berhujah menjadikan perjanjian itu batal, Iran telah memajukan programnya dengan ketara dengan menyimpan uranium yang diperkaya hampir gred senjata ke tahap yang, jika diperkaya lagi, boleh menghasilkan senjata nuklear, serta keupayaan sentrifuge dan misilnya.Apabila ditanya oleh Digital jika Grossi menilai kedudukan Republik Islam itu jujur, beliau berkata, "Percaya, tetapi sahkan. Kita perlu mengesahkan.""Kami adalah pemeriksa — itulah satu-satunya cara kami membina kepercayaan," tambahnya.Grossi berkata pentadbiran perlu mengenal pasti apakah matlamat akhir perjanjian terbaharu ini, kerana rangka kerja JCPOA — yang dikritik hebat oleh Trump — kini sangat lapuk disebabkan kemajuan yang telah dicapai oleh Iran.Isu-isu seperti simpanan uranium, inventori, kemajuan sentrifuge dan keupayaan senjata nuklear semuanya ada di atas meja dalam rundingan AS-Iran."Kami mempunyai bidang yang jauh lebih kompleks di hadapan kami," Grossi memberi amaran. "Perkara yang baik ialah kita tahu apa yang perlu kita lihat. Kita mempunyai perspektif yang unik tentang itu."Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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India merendahkan hubungan dengan Pakistan selepas serangan ke atas pelancong Kashmir Berita

India merendahkan hubungan dengan Pakistan selepas serangan ke atas pelancong Kashmir

(SeaPRwire) - India mengumumkan beberapa langkah untuk menurunkan hubungannya pada hari Rabu, sehari selepas militan yang disyaki membunuh 26 orang lelaki di destinasi pelancongan di Kashmir dalam serangan terburuk terhadap orang awam di negara itu dalam hampir dua dekad. memberitahu taklimat media bahawa kaitan rentas sempadan serangan itu telah "dibawa keluar" pada mesyuarat khas kabinet keselamatan, selepas itu diputuskan untuk bertindak terhadap Pakistan.Beliau berkata New Delhi akan menggantung serta-merta perjanjian air sungai penting yang membenarkan perkongsian air sistem sungai Indus antara kedua-dua negara.Penasihat pertahanan di suruhanjaya tinggi Pakistan di New Delhi telah diisytiharkan sebagai persona non grata dan diminta untuk pergi, kata Misri, sambil menambah bahawa kekuatan keseluruhan suruhanjaya tinggi India di Islamabad akan dikurangkan kepada 30 daripada 55.Pusat pemeriksaan lintasan sempadan utama antara kedua-dua negara akan ditutup serta-merta dan warga Pakistan tidak akan dibenarkan melancong ke India di bawah visa khas, kata Misri.Sekurang-kurangnya 17 orang juga cedera dalam kejadian tembakan yang berlaku pada hari Selasa di lembah Baisaran di kawasan Pahalgam di wilayah persekutuan Himalaya yang indah di Jammu dan Kashmir. Yang mati termasuk 25 warga India dan seorang warga Nepal, kata polis. Ia merupakan serangan terburuk terhadap orang awam sejak kejadian tembakan Mumbai 2008, dan memecahkan ketenangan relatif di Kashmir, di mana pelancongan telah berkembang pesat apabila pemberontakan anti-India telah berkurangan dalam beberapa tahun kebelakangan ini.Sebuah kumpulan militan yang tidak dikenali, "Kashmir Resistance," mengaku bertanggungjawab atas serangan itu dalam mesej media sosial. Ia menyatakan rasa tidak puas hati bahawa lebih daripada 85,000 "orang luar" telah ditempatkan di rantau itu, mendorong "perubahan demografi".Agensi keselamatan India mengatakan Kashmir Resistance, juga dikenali sebagai The Resistance Front, ialah barisan hadapan untuk organisasi militan yang berpangkalan di Pakistan seperti Lashkar-e-Taiba dan Hizbul Mujahideen.Pakistan menafikan tuduhan bahawa ia menyokong keganasan militan di Kashmir dan mengatakan ia hanya memberikan sokongan moral, politik dan diplomatik kepada pemberontakan di sana.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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HighTide Therapeutics to Showcase New Analyses of Phase 2 MASH/T2DM Studies of Berberine Ursodeoxycholate (HTD1801) and Pre-Clinical Results of Rimtoregtide (HTD4010) in Presentations at EASL Congress 2025 ACN Newswire

HighTide Therapeutics to Showcase New Analyses of Phase 2 MASH/T2DM Studies of Berberine Ursodeoxycholate (HTD1801) and Pre-Clinical Results of Rimtoregtide (HTD4010) in Presentations at EASL Congress 2025

HONG KONG, Apr 24, 2025 - (ACN Newswire via SeaPRwire.com) – HighTide Therapeutics, Inc. (2511.HK), a clinical stage biopharmaceutical company specializing in the development of multifunctional multi-targeted therapies for chronic liver and metabolic diseases, announced today that it will present at the EASL Congress 2025, taking place from May 7-10, 2025 in Amsterdam. The presentations include post-hoc analyses of two Phase 2 clinical studies of berberine ursodeoxycholate (HTD1801), a gut-liver anti-inflammatory metabolic modulator, being developed for treatment of metabolic dysfunction-associated steatohepatitis (MASH) and type 2 diabetes mellitus (T2DM). A third presentation will present preclinical results for rimtoregtide (HTD4010), a peptide derived from the Reg3a protein, in liver failure in mice.“Effects of Berberine Ursodeoxycholate (HTD1801) in Patients with At-risk MASH and T2DM”(Presentation SAT-440, Poster Presentation, May 10, 8:30 AM CET)About the Abstract: Due to the ongoing unmet medical need, clinical development in MASH focuses on patients who are at a higher risk of disease progression and outcomes due to the presence of moderate to advanced fibrosis (defined as at-risk MASH). The purpose of this analysis was to assess the effects of HTD1801 in patients with at-risk MASH and T2DM as defined by baseline MRI cT1 >875 ms. Eighteen weeks of treatment with HTD1801 resulted in substantial improvements in key hepatic and cardiometabolic parameters in patients with at-risk MASH and compared to placebo, twice as many patients achieved a reduction in liver fat content (MRI-PDFF) or fibroinflammation (cT1) that have been associated with improvements in liver histology. These data are particularly insightful as HTD1801 continues to be evaluated in an ongoing paired biopsy study of patients with at-risk MASH and pre-diabetes or diabetes.“Effects of Berberine Ursodeoxycholate (HTD1801) in Chinese Patients with T2DM and Presumed MASLD”(Presentation SAT-432, Poster Presentation, May 10, 8:30 AM CET)About the Abstract: T2DM typically coexists with other metabolic abnormalities such as hyperlipidemia, obesity, and MASH that can exacerbate T2DM and can lead to a worse prognosis with increased risk for mortality and cardiovascular outcomes. In a Phase 2 study in patients with T2DM, HTD1801 achieved the primary endpoint with a significant decrease in HbA1c. Based on the latest diagnostic criteria, it is likely that a substantial subgroup of the study may have had concurrent metabolic dysfunction-associated steatotic liver disease (MASLD). The purpose of this analysis was to evaluate the benefits of HTD1801 in patients with T2DM and MASLD identified by baseline controlled attenuation parameter values >288 dB/M (correlated to 5% liver fat content). HTD1801 treatment demonstrated both dose-dependent improvements in cardiometabolic and hepatic parameters in patients with T2DM and MASLD. These data suggest HTD1801 can comprehensively address metabolic and cardiovascular risk factors beyond glycemic control.“A Comparison of the Protective Effects of Rimtoregtide (HTD4010) and DUR-928 on Acute Liver Failure in Mice”(Presentation FRI-141, Poster Presentation, May 9, 8:30 AM CET)About the Abstract: The purpose of this study was 1) to test the potential protective effects of HTD4010 in an LPS-induced model mimicking acute liver failure in mice and 2) compare these effects to DUR-928, which is currently in late-stage development for the treatment of alcohol-associated hepatitis. In an LPS-induced mouse model mimicking acute liver failure, HTD4010 resulted in significant improvement in survival rates (greater than 2-fold) compared to the model control. These protective effects of HTD4010 were significantly greater than DUR-928. These findings provide evidence that HTD4010 may have a beneficial effect on acute liver conditions including alcohol-associated hepatitis and other acute-inflammatory-related conditions.About Berberine UrsodeoxycholateBerberine ursodeoxycholate (HTD1801) is an orally delivered, gut-liver anti-inflammatory metabolic modulator being developed for the treatment of metabolic and digestive diseases. HTD1801, an ionic salt of berberine and ursodeoxycholate, is a new molecular entity with a unique dual mechanism of action: AMP kinase activation and NLRP3 inflammasome inhibition. These two key mechanistic pathways have been associated with improvements in insulin resistance, glucose metabolism, lipid metabolism, and hepatic inflammation, potentially providing a comprehensive treatment platform for the multifaceted nature of complex metabolic diseases. HTD1801 is being developed for multiple indications. HTD1801 met the primary endpoint in two Phase 3 clinical trials in patients with type 2 diabetes mellitus (T2DM), demonstrating a clinically meaningful effect on HbA1c. In both trials, key secondary endpoints were achieved, suggesting multiple advantages of HTD1801 including improvement in cardiometabolic risk indicators. In addition to T2DM, HTD1801 efficacy in treating metabolic dysfunction-associated steatohepatitis (MASH) has been demonstrated in a Phase 2a clinical trial, and a global multicenter Phase 2b trial assessing the histologic benefit of HTD1801 is currently ongoing, with topline results expected in 2025.About RimtoregtideRimtoregtide (HTD4010) is a clinical-stage compound in development for acute inflammatory-related indications including alcoholic hepatitis (AH). It is a peptide derived from the Reg3a protein with immunomodulatory, anti-inflammatory, and anti-apoptotic effects. HTD4010 has been evaluated in animal models of acute pancreatitis and acute liver failure, where protective effects were observed. A completed Phase 1 clinical trial of HTD4010 in healthy subjects demonstrated a favorable safety profile. AH is caused by chronic heavy alcohol abuse or a sudden, drastic increase in alcohol consumption. It is characterized by severe inflammation and, ultimately, liver failure and death. There is currently no approved treatment for AH and only a few drug candidates are in clinical development. The current standard of care focuses on symptom management, including abstinence, treating inflammation and providing nutrition.About HighTide TherapeuticsHighTide Therapeutics, Inc. (Stock Code: 2511.HK) is a globally integrated biopharmaceutical company focusing on the discovery and development of first-in-class multifunctional, multi-targeted therapies with poly-indication potential across metabolic diseases with significant unmet medical needs. HighTide is currently developing several clinical assets and associated global intellectual property rights, and advancing multiple mid-to-late-stage clinical trials including therapies for metabolic dysfunction-associated steatohepatitis (MASH), type 2 diabetes mellitus (T2DM), severe hypertriglyceridemia (SHTG) and primary sclerosing cholangitis (PSC). Berberine ursodeoxycholate (HTD1801), HighTide’s lead drug candidate, received Fast Track designation from the United States Food and Drug Administration for both MASH and PSC and Orphan Drug designation for PSC. HTD1801 has been included in the National Major New Drug Innovation Program under the 13th Five-Year Plan for Major Technology Project in China.For more information, please visit www.hightidetx.comContact: pr@hightidetx.com Copyright 2025 ACN Newswire via SeaPRwire.com.
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TransNusa Increases Scheduled Flight Frequency to Singapore ACN Newswire

TransNusa Increases Scheduled Flight Frequency to Singapore

JAKARTA, Apr 24, 2025 - (ACN Newswire via SeaPRwire.com) - South East Asia’s first premium service airline, PT TransNusa Aviation Mandiri, is further strengthening its presence in Singapore by increasing the frequency of its scheduled flights for the Jakarta – Singapore route to two times daily from today.This announcement comes barely a month after TransNusa successfully launch scheduled flights to Perth from its base in Bali.TransNusa Group Chief Executive Officer, Datuk Bernard Francis said that TransNusa has plans to further strengthen its network connectivity this year.In line with this, TransNusa launched its second daily flight to Singapore today. The additional flight, 8B 153, departed at 12.10pm from the Terminal 3 Soekarno – Hatta International Airport and arrived Singapore Changi Airport at 14.40pm today. While its additional flight, 8B 154, departed Changi Airport at 15.30pm and arrived at the Soekarno – Hatta International Airport at 16.20pm.“TransNusa will continue to operate the current scheduled flight, 8B 151, which depart Soekarno – Hatta International Airport at 07.55am and arrive at 10.45am at the Changi Airport,” Datuk Bernard said, adding that the current flight, 8B 152, depart Changi Airport at 11.45am and arrive in Jakarta at 12.30pm.TransNusa has been consistently achieving milestones since the introduction of a new top management led by aviation veteran, Datuk Bernard Francis. The airline, which introduced its first international flight on April 14, 2023, has expanding its wings from South East Asia to the Asia Pacific region within a short span of 2 years.Datuk Bernard attributes the airline’s successes and accelerated growth within the last 24 months to their customised business model and the vastly experienced management team.Datuk Bernard stressed that for its international flights, TransNusa not only provide premium services with competitive ticket prices, but the airline also has attractive product bundles called SEAT, SEAT-PLUS and FLEXI-PRO."Our passengers will enjoy check-in baggage of between 20kgs to 30 kgs, depending on the product purchased,” Datuk Bernard said, explaining that the baggage offering was over and above the 7kgs limit offered as a passenger’s hand carry.“For the highest package, FLEXI-PRO, we provide more complete services such as free baggage 30kgs, free to choose seats, free food, and drinks, priority at check-in and boarding. In addition, TransNusa also provides its FLEXI-PRO passengers with the ability to be able to change their flight schedule without restrictions and obtain refund when needed.”TransNusa, which aims to ensure its passengers travel with ease and comfort, has also configured their A320s with a 174-seat configuration, which allows for passengers to enjoy about 30 inches of legroom, comparable to the experience passengers would get in a full-service airline."We are committed to providing affordable and competitive ticket prices, while still providing premium services to our customers.” said Datuk Bernard, adding that the ticket price for the Jakarta – Singapore route starts from as low as SGD52 (USD40).DATUK BERNARD FRANCIS… TransNusa to focus on strengthening network connectivityTransNusa, A Short HistoryTransNusa, which had to close it business operation in September 2020 due to impact of the Covid-19 pandemic on the aviation industry, started operations again after injection of new shareholders and a new management team led by aviation expert, Datuk Bernard, in October 2022.Within 6 months, the airline introduced its first international route between Jakarta and Kuala Lumpur and celebrated its first-year anniversary for this route on April 14, 2024.“When we re-launched TransNusa in October 2022, we started from the bottom again. Everything was new because the pandemic had disrupted the aviation business operations boundaries. As such we re-created and customised our business operations and strategy model of being the first Premium Service Carrier based on the post-pandemic scenario,” Datuk Bernard explained.TransNusa launched its first international route between Jakarta and Kuala Lumpur in April, 2023, followed by the Jakarta – Singapore route on November 20, 2023. After which, the airline successfully launched three more new international routes by the end of 2023. TransNusa’s aggressive international growth strategy combined with its domestic business operations approach has enabled the airline to experience strategic growth in the last two years.Since the takeover of new shareholders and the injection of a new management team, TransNusa has been making headlines in Malaysia, Singapore, China and Australia with news of being the first airline in Indonesia and the world to develop and introduce a new domestic route connecting Bali and Manado. TransNusa also became the second Indonesian airline to receive approval to fly to China.About TransNusaEstablished in 2005, TransNusa started its operation by providing chartered flights. It began its commercial flights in 2011. After ceasing operations due to the Covid-19 pandemic, TransNusa relaunched itself in 2021 as a low-cost airline in its domestic market. In 2023, TransNusa introduced a new business model making it the first Premium Service Airline in the region. The new business model will apply only to its international routes. TransNusa introduced its first international route in April this year. The airline introduced its Jakarta – Kuala Lumpur round trip route and had its maiden flight on April 14. The airline is currently based in Jakarta Soekarno-Hatta International Airport.Passengers can book their flights on the TransNusa website (www.transnusa.co.id), through authorized travel agents in Singapore and Indonesia, or by contacting the airline's customer service centre at, +62216310888. For the Singaporean market, passengers can contact TransNusa’s General Sales Agent, Chariot Travels Pte Ltd, at +65 86602719.Media ContactTrina Thomas Rajtrina@myqaseh.org+60124992672 (watsapp) Copyright 2025 ACN Newswire via SeaPRwire.com.
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NEC invests in U.S.-based “Geodesic Alliance Fund” aiming to strengthen economic security business JCN Newswire

NEC invests in U.S.-based “Geodesic Alliance Fund” aiming to strengthen economic security business

TOKYO, Apr 24, 2025 - (JCN Newswire via SeaPRwire.com) - NEC Corporation (NEC; TSE: 6701) has announced an investment in the "Geodesic Alliance Fund, L.P." (hereafter, "the Fund"), a fund managed by the U.S. venture capital (VC) firm "Geodesic Investments, L.L.C." (hereafter, "Geodesic"), with the aim of strengthening its business in the area of economic security, including space, submarine cables, cyber security and national defense.In the United States, private-sector-led innovation is progressing under a thriving startup ecosystem. In addition to private funds, government agencies in the U.S. are also actively investing and public-private partnerships that incorporate consumer technologies are deepening, leading the world in investment, technology development, and commercialization.Geodesic, whose founding partner John V. Roos is a former U.S. Ambassador to Japan, is a rare venture capital firm that has both an investment team with expertise in the field of startups and a team that supports the promotion of collaboration between Japanese companies and international startups. The Fund is managed by Geodesic and invests in startups, mainly in the United States, specializing in the field of economic security.Through this investment, NEC will gain a better understanding of the latest industry and technological trends in areas such as space, submarine cables, cyber security and national defense, and will apply this to its future business strategies. Moreover, by quickly identifying and collaborating with startups that have excellent technological capabilities, NEC will be strengthening its future business competitiveness.NEC provides a wide range of solutions in the economic security domain and develops advanced technologies to support these solutions. Going forward, NEC will continue to create social value through co-creation with external parties while leveraging its extensive domain knowledge and technological capabilities, thereby contributing to the realization of a society in which all people can share a sense of peace and assurance.About NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of “Orchestrating a brighter world.” NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com. Copyright 2025 JCN Newswire via SeaPRwire.com.
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MHI Thermal Systems Wins German Red Dot Design Award 2025 JCN Newswire

MHI Thermal Systems Wins German Red Dot Design Award 2025

TOKYO, Apr 24, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries Thermal Systems, Ltd. (MHI Thermal Systems), a part of Mitsubishi Heavy Industries (MHI) Group, has received the Red Dot Design Award 2025, an international design competition in Germany, for its RC-ES1 remote control unit for air-conditioners for overseas markets.(1)The Red Dot Design Award is an international design competition established in Germany in 1955. It is one of the world's three major design awards, along with IDEA in the United States, and the iF DESIGN AWARD in Germany. The Red Dot Design Award is divided into three categories: Product Design, Brands & Communication Design, and Design Concept. The stylish new RC-ES1 has received an award in the Product Design category.The RC-ES1 is a remote control developed for air-conditioners used in stores, offices and hotels. It features a sophisticated exterior designed by Tensa Industrial Design, headquartered in Milan, Italy. The black tone color, and the compact and flat structure (86 mm x 86 mm x 17 mm), beautifully match many different types of interiors. The functions available on remote control itself is simplified by adopting pictogram where diverse users can understand and operate easily regardless of their nationality or ages.In addition, the RC-ES1 supports Bluetooth® wireless technology,(2) allowing for operation and configuration from a smartphone using a dedicated app. The app has three modes (User, Administrator, and Service), providing a wide range of functions according to the application, such as the operation of the remote control, or saving, transferring setting data and checking inspection data for indoor units and remote controls. With all modes the input setting on app can be automatically and continuously transmitted to up to 20 remote control units within the Bluetooth® wireless connection range from a single smartphone.Going forward, through receiving this award, MHI Thermal Systems will continue to develop technologies and products well suited to customers, aiming to provide heating and cooling solutions that meet diverse needs.(1) For more information about the RC-ES1, see the following press release.https://www.mhi.com/news/240703.html(2) The Bluetooth® word mark and figure mark are registered trademarks, and are the property of Bluetooth SIG, Inc. MHI Thermal Systems uses these trademarks under license. All other trademarks and registered trademarks are the property of their respective owners.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com.
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ULVAC Develops Dilution Refrigerator for Quantum Computers JCN Newswire

ULVAC Develops Dilution Refrigerator for Quantum Computers

Chigasaki, Japan, Apr 24, 2025 - (JCN Newswire via SeaPRwire.com) - ULVAC, Inc. and ULVAC CRYOGENICS INC. have successfully developed a dilution refrigerator*1 designed for quantum computing applications. On April 4, 2025, the unit was installed at a leading quantum research institute*2 in Japan. This achievement marks a critical milestone in the development of the country’s first fully Japan-built quantum computer—realized using only domestically developed core components.Until now, Japan has faced the long-standing challenge of building a quantum computer entirely from domestically sourced technologies. ULVAC’s cryogenic solution, now operating as a core part of this quantum system, demonstrates Japan’s growing competitiveness in the global quantum race. Localized development enables flexible scalability, secure supply chains, and lower operational risks for users. Among these elements, the dilution refrigerator—ensuring a stable cryogenic environment essential for high-precision qubit operations—plays a vital role in enabling both deployment and long-term usability.This quantum computer will be publicly demonstrated at the Expo 2025 Osaka, Kansai, Japan during the “entangle moment - [quantum | earth | universe] × art”*3 event, to be held from August 14–20. Visitors will be able to interact with the system via the cloud, experiencing real-time quantum operations firsthand.A Fully Japan-Made Quantum ComputerThe new system integrates all major subsystems—including the refrigerator, control electronics, and qubit chips—based on technologies developed in Japan. ULVAC led the development of the dilution refrigerator, which provides a stable cryogenic temperature of approximately 10 mK over extended periods, essential for the precise and reliable operation of qubits.The development team overcame numerous engineering challenges, such as maximizing cooling efficiency, minimizing vibration, and managing thermal contraction under cryogenic conditions. These were addressed through custom flow path design, precision component fabrication, and advanced thermal-stress simulations. Through extensive prototyping and testing, the system achieved reliable and consistent cryogenic performance.In anticipation of future scaling, ULVAC adopted a modular architecture, allowing the system to evolve from laboratory environments to real-world quantum computing platforms. Additionally, all critical cryogenic and vacuum technologies—including dilution refrigerators, pulse tube cryocoolers, and vacuum components—are developed and manufactured in-house. This integrated supply chain ensures long-term availability and support, meeting both current and future demands from advanced research facilities.“It has been a great honor, as a cryogenic engineer, to contribute to the cooling of a quantum computer using technologies developed entirely in Japan. Seeing our dilution refrigerator operate at the forefront of quantum innovation is deeply rewarding. This project marks just the beginning—we are committed to continuously advancing cryogenic performance and reliability for the future of quantum computing.”- Dr. Masamichi Saitoh, Lead Engineer at ULVAC CRYOGENICS INC., who oversaw the development of the dilution refrigeratorFuture ProspectsULVAC’s dedication to advancing quantum computing goes beyond this domestic collaboration. As leading players in the global quantum ecosystem increasingly recognize its strengths, ULVAC is emerging as a key enabler of next-generation technologies. By leveraging its deep expertise in vacuum and cryogenic technologies developed in Japan, the company will continue to support the growth of scalable quantum infrastructure and contribute to solving critical challenges facing future society.*1 This research was partially supported by the Japan Science and Technology Agency (JST) under the Moonshot Research & Development Program. It falls under Moonshot Goal 6: “Realization of a fault-tolerant universal quantum computer that will revolutionize economy, industry, and security by 2050” (Program Director: Dr. Masahiro Kitagawa), part of the R&D project “Development of Integration Technologies for Superconducting Quantum Circuits” (Project Manager: Dr. Tsuyoshi Yamamoto), specifically the research theme “Development of Cryogenic Systems Specialized for Quantum Computing” led by Dr. Masamichi Saitoh (Project No. JPMJMS2067).*2 The dilution refrigerator was installed at the Center for Quantum Information and Quantum Biology, The University of Osaka.*3 Expo 2025 Osaka, Kansai, Japan “entangle moment - [quantum | earth | universe] × art”About ULVAC, Inc.Since its founding in 1952, ULVAC, Inc. has been a comprehensive vacuum equipment manufacturer, providing manufacturing equipment, components, analytical instruments, materials, and services based on its core technology—vacuum technology. Working with customers across a wide range of industries, including semiconductors, electronic components, displays, automotive, and pharmaceuticals, ULVAC is committed to driving cutting-edge innovation and creating new value. https://www.ulvac.co.jp/en/About ULVAC Cryogenics Inc.Since its founding in 1981, ULVAC Cryogenics Inc. has been engaged in the development, manufacturing, and sales of cryopumps and cryogenic equipment utilizing cryogenic and control technologies. The company was founded through the integration of the vacuum technology of Japan Vacuum Engineering Co., Ltd. (now ULVAC, Inc.) and the refrigeration technology of the U.S.-based Helix Technology Corporation (now Edwards Vacuum LLC). In Japan, ULVAC Cryogenics holds a 40% market share in cryopump sales. https://www.ulvac-cryo.com/?lang=enFor more information:ULVAC CRYOGENICS INC. Sales Planning DepartmentTEL +81-467-85-8884 / Mail cryokikaku@ml.ulvac.com Copyright 2025 JCN Newswire via SeaPRwire.com.
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Waterloo Startup Axibo AI Secures $12M to Pioneer ‘Made in Canada’ Humanoids ACN Newswire

Waterloo Startup Axibo AI Secures $12M to Pioneer ‘Made in Canada’ Humanoids

WATERLOO, ONTARIO, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) - Axibo Inc., a Waterloo-based robotics innovator celebrated for its groundbreaking 4D volumetric capture technologies and serving customers like Netflix and Apple, today announced a $12 million funding round. This investment includes $11 million from prominent external investors and an additional $1 million from Axibo's founders Anoop Gadhrri, Sohaib Al-Emara, and Reiner Schmidt, whose passion for robotics began back in 2019 with their university's first autonomous vehicle. The funding launches Axibo's ambitious new division dedicated to advanced humanoid robotics.Axibo FoundersWith a track record of thousands of cinema robots delivered internationally, Axibo will now be leveraging Waterloo's exceptional AI, robotics, and precision engineering talent to spearhead advancements in humanoid robotics."We see humanoid robots as the next major milestone in productivity since the Industrial Revolution," said Anoop Gadhrri, co-founder and CEO of Axibo. "Canada is exceptionally well-positioned with its talent and resources. Our commitment is to drive this forward, placing Canada prominently on the global robotics stage."Axibo is actively seeking visionary engineers passionate about developing unprecedented technologies and shaping the global future of humanoid robotics. Early team members will not only create groundbreaking prototypes but directly contribute to substantial societal advancements through robots engineered for safe and intelligent integration into healthcare, logistics, industrial automation, and personal assistance. By fostering an innovation-driven culture emphasizing rapid prototyping and autonomy, Axibo empowers its engineers to experiment freely and iterate swiftly."We envision a future where every household benefits from humanoid robotics," Gadhrri emphasized. "Axibo's technology aims to significantly elevate productivity and everyday life across Canada and beyond."The company's immediate milestones include accelerating proprietary manufacturing processes, expanding its engineering and AI teams, and advancing capabilities in robot autonomy and dexterity. The new division's first robot prototype, temporarily code-named "T.E.B.", will debut in early 2026, demonstrating advanced agility and intelligence.If you're ready to build what's next in robotics, Axibo invites you to join the pioneering team positioning Canada at the global forefront of robotics innovation.To learn more or apply, visit axibo.ai.Contact InformationAnoop GadhrriCEOanoop@axibo.com6476675999SOURCE: Axibo Inc.Related Images Copyright 2025 ACN Newswire via SeaPRwire.com.
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Fujitsu expands strategic collaboration with Supermicro to offer total generative AI platform JCN Newswire

Fujitsu expands strategic collaboration with Supermicro to offer total generative AI platform

Kawasaki, Japan and San Jose, California, Apr 23, 2025 - (JCN Newswire via SeaPRwire.com) - Fujitsu Limited and Super Micro Computer, Inc. are deepening their strategic collaboration in AI computing to facilitate the secure application of generative AI within dedicated environments. As a result, the two companies, alongside the wider Fujitsu Group, today announced the launch of the PRIMERGY GX2570 M8s, a Supermicro OEM server product featuring a high-performance GPU, SupportDesk, a high-quality maintenance and operational support service for Supermicro products offering the world's first maintenance provision for the company's liquid-cooled and GPU servers, and Infrastructure Manager, an integrated management tool designed to simplify server administration. Starting in July 2025, Fujitsu will combine these OEM products, maintenance services, and integrated management tools with its Takane large language model (LLM) for enterprises, to offer a managed services for building generative AI infrastructure, allowing customers to leverage generative AI without the need to own the assets.The use of generative AI in handling confidential or personal information introduces risks such as unintended learning, data breaches, and compliance with internal data storage policies. As a result, a dedicated environment is often required, which requires significant computing power and various expertise. Therefore, there is a demand for servers equipped with high-performance GPUs, and for support for maintenance and operation, as well as management tools that easily support the stable operation of servers.The PRIMERGY GX2570 M8s is a server designed for large-scale generative AI applications and will be offered in two cooling configurations: a 10U air-cooled model and a 4U liquid-cooled model, both featuring the advanced NVIDIA HGX B200 GPU.The SupportDesk maintenance and operation support service will offer high-quality support for Supermicro servers provided by Fujitsu Group, including on-site response to addresses in Japan within approximately 2 hours achieved through a network of 4,000 experienced engineers at 700 engineer locations nationwide.The Infrastructure Manager integrated management tool simplifies the management of the server lifecycle, including deployment, monitoring, and updates, a key priority for enterprise companies. It enables integrated operation and management of Supermicro GPU-equipped servers and Fujitsu Group's existing PRIMERGY line of x86 servers, freeing up time for customers to focus on utilizing middleware and applications.The managed service provided by Fujitsu encompasses these OEM products, as well as maintenance, and integrated management services, in addition to generative AI models such as Takane, allowing customers to easily utilize generative AI infrastructure of the required size without owning the assets. Through the provision of this managed service, Fujitsu will enable customers to rapidly launch generative AI infrastructure, reduce infrastructure maintenance and management costs, and contribute to customers' generative AI utilization and business transformation.Kazushi Koga, Corporate Executive Officer, Fujitsu Limited, comments:“By strengthening its collaboration with Supermicro, Fujitsu has created a comprehensive managed service offering that combines OEM servers with high-performance GPUs for generative AI in dedicated environments, along with high-quality maintenance, integrated management services and the Takane LLM for enterprises. We are confident that this initiative is an innovative step toward promoting safe and secure generative AI utilization and will contribute to the expansion of our customers' businesses.”Charles Liang, president and CEO, Super Micro Computer, Inc., comments:“Supermicro is excited to continue its strong relationship with Fujitsu. We believe the combination of Supermicro’s 10U air-cooled model and a 4U liquid-cooled model, both featuring the advanced NVIDIA HGX B200 GPU family, with Fujitsu’s recognized global service offer customers a proven AI solution for the accelration of AI in the enterprise.”About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers in over 100 countries, our 124,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: Computing, Networks, AI, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.7 trillion yen (US$26 billion) for the fiscal year ended March 31, 2024 and remains the top digital services company in Japan by market share. Find out more: www.fujitsu.com.Press ContactsFujitsu Limited Public and Investor Relations DivisionInquiries Copyright 2025 JCN Newswire via SeaPRwire.com.
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EdgePoint Towers advances renewable energy integration in telecommunications with first solar hybrid deployment ACN Newswire

EdgePoint Towers advances renewable energy integration in telecommunications with first solar hybrid deployment

KUALA LUMPUR, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) - EdgePoint Towers Sdn Bhd (“EdgePoint”) – part of EdgePoint Infrastructure, a leading ASEAN-based independent telecommunications infrastructure company, has successfully launched its first solar hybrid site, marking a key milestone in its renewable energy initiatives. This deployment represents a significant step toward advancing sustainable energy solutions in Malaysia’s telecommunications sector.The new solution provides up to 100% of the energy required to operate telecommunications equipment, reducing dependence on diesel fuel. With a 5.9-kilowatt peak (kWp) capacity, the site operates autonomously using photovoltaic (solar) energy, complemented by battery storage.Muniff Kamaruddin, Chief Executive Officer of EdgePoint Towers, said, “We are proud to contribute to the deployment of renewable energy solutions that meet current and future needs for both sustainability and long-term cost efficiency. These solutions are especially important for remote and difficult-to-reach areas, such as transport corridors like highways, tunnels, bridges, or terminals, where quality coverage is essential for transient users. The opportunities to enhance national connectivity are vast, and EdgePoint is eager to continue working closely with our partners to advance sustainable solutions that improve coverage and reduce carbon emissions across the industry. This deployment is expected to reduce the site's annual carbon emissions by approximately 78%, while also ensuring seamless connectivity for travelers along the highway.”Muniff concluded, “Solar energy has proven to be an ideal solution for Malaysia, given its equatorial climate and high levels of solar insolation. By integrating solar power into telecommunications infrastructure, we are reducing reliance on non-renewable energy sources, lowering operational costs, and significantly decreasing emissions. Solar hybrid solutions are an adjacent focus area for us, it is a key part of our broader strategy of implementing innovative, sustainable solutions, driving an industry-wide transformation toward cleaner, more efficient operations and we are optimistic about future collaborations with both Mobile Network Operators (MNOs) and non-MNO clients to help them meet their green objectives. As we expand our renewable energy initiatives, we aim to set new benchmarks for energy-efficient telecom infrastructure in Malaysia, helping our partners transition to greener operations without compromising connectivity, network quality, and reliability.”By the end of 2025, EdgePoint plans to complete more full solar or solar hybrid sites across the country, further strengthening its commitment to sustainable telecom infrastructure.EdgePoint Infrastructure is the fastest-growing multi-country tower company in ASEAN, with 15,800 sites in its portfolio out of which 1,800 sites are in Malaysia making it the second-largest tower company in Malaysia.****ABOUT EDGEPOINT INFRASTRUCTUREEdgePoint Infrastructure is an ASEAN based independent telecommunications infrastructure company that aspires towards Building a Connected, Digital ASEAN. Headquartered in Singapore with operations in Malaysia, Indonesia and the Philippines, through EdgePoint Towers Sdn Bhd, PT Centratama Telekomunikasi Indonesia, Tbk and EdgePoints Towers Inc. respectively, the company is focused on providing sharable and leading-edge telecom structures, small cells and in-building systems. EdgePoint aims to be an industry leader through scale and innovation, driving operational efficiencies through the adoption of analytics and digital technologies. For more information on EdgePoint, please visit https://edgepointinfra.com/. Copyright 2025 ACN Newswire via SeaPRwire.com.
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Batch Bicycles and Hyatt Place Zhuhai jointly organized An Exhalating Cycling Event in Macau ACN Newswire

Batch Bicycles and Hyatt Place Zhuhai jointly organized An Exhalating Cycling Event in Macau

HONG KONG, Apr 23, 2025 - (ACN Newswire via SeaPRwire.com) – On 22 April, Earth Day, an electrifying cycling event was held across Guangdong and Macau. Batch Bicycles and Hyatt Place Zhuhai jointly organised Ride Macao, an event to explore the country on wheels and celebrate Earth's Day with green travel.In today’s fast-paced city life, people are often busy with work and various affairs that they gradually leave nature and sports behind. The Ride Macao event was designed to break this shackle and spread the values of living green, protecting the environment and the cycling lifestyle to everyone.Starting from Hyatt Place Zhuhai and arriving at Hengqin Port, the carefully planned route combined the picturesque natural scenery and unique cityscape along the way with the ease of cruising through customs. Riders enjoyed the magnificent view of the sea and sky during the journey while also experiencing the unique charm of the blend of history and modernity found along the streets and lanes of Macau. This was not only a long-distance ride, but also a deep dialogue with the earth to embrace green living.Ride Macau by Batch Bicycles (a brand of Covation)Batch Bicycles Products DisplayBatch Bicycles is a global brand of Covation Holdings Limited (Covation). Covation is a global holding company headquartered in Hong Kong. Covation's vision of consumer-centric innovation is driven by its diverse portfolio of outdoor brands, including Huffy, Niner Bikes, Batch Bicycles, Royce Union, VAAST and Buzz E-Bikes, which are available to consumers in more than 50 countries and territories around the world through an extensive global distribution network. The company ships more than 5 million bicycles annually. Covation holds a wide-ranging licensing portfolio with world-class partners such as Disney, Marvel, Lucasfilm, National Geographic, Ford, Nickelodeon, Hasbro, and Panama Jack. The vast distribution network includes leading global retailers such as Walmart, Amazon, Target, Swire, Big W, Academy, Argos, Smyths, and many other international outlets.The mission of Batch Bicycles is to 'make cycling easier'. With a wide range of products including mountain bikes for conquering mountains, road bikes for riding the pavement, gravel bikes and cycling equipment specially designed for teenagers. Batch Bicycles are designed to provide cycling enthusiasts around the world with a comfortable and smooth cycling experience through innovative designs and high-quality configurations. The Macao Ride is a vivid manifestation of Batch Bicycles brand philosophy to make cycling easier and encourage people to venture out of the concrete city to explore the world and embrace nature through cycling. Copyright 2025 ACN Newswire via SeaPRwire.com.
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